Mesothelioma Symptoms

What are the most common warning signs of mesothelioma?

Mesothelioma is difficult to diagnose because the early signs and symptoms of the disease can be subtle or mistaken. Symptoms are all too frequently ignored or dismissed by people who are inclined to attribute them to common every day ailments. Sometimes patients live with symptoms for up to 6 months before being diagnosed but usually the symptoms are present for two to three months prior to a mesothelioma diagnosis.

About 60% of patients diagnosed with pleural mesothelioma experience lower back pain or side chest pain and there are frequent reports of shortness of breath. Lower numbers of people may experience difficulty swallowing, or have a persistent cough, fever, weight loss or fatigue. Additional symptoms that some patients experience are muscle weakness, loss of sensory capability, coughing up blood, facial and arm swelling and hoarseness.

Peritoneal mesothelioma originates in the abdomen and as a result, symptoms often include abdominal pain, weight loss, nausea, and vomiting. In the event that there is a hernia present, fluid buildup may occur in the abdomen as well.

Asbestos exposure is considered the primary risk factor for the development of the cancer. Anyone previously exposed to asbestos displaying any of these symptoms should seek medical attention from a doctor who specializes in the treatment and diagnosis of mesothelioma and thoracic oncology.

How long does it take for mesothelioma symptoms to appear?

One of the most unique facts about mesothelioma is that the disease is characterized by a long latency period that is very often associated with the disease. The latency period is the amount of time that elapses from the first point of asbestos exposure to the point where symptoms begin to appear so that a diagnosis can be made. In some mesothelioma cases the latency period is reported to be 10 years but the average latency for the majority of cases is between 35 and 40 years. As a result, the cancer often progresses to later stages before a diagnosis is made. When diagnosed in the later stages, mesothelioma treatment options become more limited and are less effective.

Symptoms of Mesothelioma

Provided below is a list of symptoms that mesothelioma patients may experience. Please click on a symptom to learn more about it.

Anemia

Mesothelioma patients diagnosed with anemia have a lower than normal red blood cell count or hemoglobin in the blood which can cause fatigue and if left untreated, result in a loss of bone marrow.

Blood Clotting Disorder

A symptom experienced by many mesothelioma patients that can lead to anemia and other serious complications if not given appropriate medical attention.

Bowel Obstruction

A very painful symptom that can sometimes develop in peritoneal mesothelioma patients due to fluid buildup in the abdomen.

Chest Pain

Often experienced in pleural mesothelioma and pericardial mesothelioma patients, chest pain can develop as the tumor grows and places strain on the lungs and heart.

Dysphagia

Pleural mesothelioma patients often develop difficulty swallowing (esophageal dyphagia) as the mesothelium continues to grow on the lungs.

Fluid Effusion

An effusion can occur in mesothelioma patients when there is fluid buildup affecting either the pleura or pericardium.

Hemoptysis

Hemoptysis, or the symptom of coughing up blood, can have its origins in the lungs, bronchi or trachea of mesothelioma patients.

Nausea

Nausea is experienced in a number of cancer patients as it is often a side effect of chemotherapy treatment. Those diagnosed with peritoneal mesothelioma may also experience nausea as a result of increasing abdominal pressure.

Peritoneal Effusion

Peritoneal mesothelioma patients may experience a buildup of fluid in the peritoneum as the tumor continues to grow. This can result in an effusion which can inhibit the function of abdominal organs.

Pleural Effusion

In pleural mesothelioma patients, pleural effusion may develop when there is a large amount of fluid present in the pleura, the lining between the lungs and chest cavity.

Weight Loss

Weight loss can occur in mesothelioma patients as a side effect from cancer treatment or as the result of other symptoms that may also be present such as difficulty swallowing or nausea.

Sources:

Ismail-Khan, Roohi. Robinson, Lary A. Malignant Pleural Mesothelioma : A Comprehensive Review. Cancer Control : Journal of the Moffit Cancer Center. 2006;13(4):255-263.

Vogelzang, Nicholas J. Rusthoven, James J. Phase III Study of Pemetrexed in Combination with Cisplatin Versus Cisplatin Alone in Patients with Malignant Pleural Mesothelioma. Journal of Clinical Oncology, Vol 21, Issue 14 (July), 2003: 2636-2644

Sugarbaker, David J. Garcia, J.P. Extrapleural Pneumonectomy on the multimodality therapy of malignant pleural mesothelioma. Results in 120 consecutive patients. Annals of Surgery 1996. September; 224(3): 288-296.